 |
|
Jacques Peschon
Area of Expertise
Manipulative mouse genetics
Inflammation
Cytokine biology
Current Position
Senior Research Scientist
Degree
Ph.D., Biochemistry, University of Washington, 1989
Research Interests
Throughout his career, Jacques has used manipulative mouse genetics to interrogate biologic systems. As a graduate student, he developed transgenic systems to understand transcriptional and translational control of gene expression in haploid male germ cells.
Jacques then helped initiate and ultimately led the gene knockout program at Immunex. His group generated induced mouse mutants to understand the roles of specific cytokines, their receptors and ancillary proteins in the development and function of hematopoietic cells during health and disease. Selected highlights include (a) revealing essential roles for the metalloproteinase ADAM17 in the processing of multiple EGFR ligands, for RANK in the development of osteoclasts and for IL17R in the mobilization of neutrophils in response to infectious challenge, (b) developing a mouse model for rheumatoid arthritis that is independent of TNF, (c) establishing a skin biology effort based on uncovering a requirement for a novel serine-threonine kinase, RIP4, in epidermal differentiation and (d) revealing potent agonist and antagonist activities of novel IL1 family members in cutaneous inflammation.
Jacques continues to be interested in cytokine biology, especially in the context of balancing protective and pathogenic activities of critical mediators of inflammation.
Selected Publications
Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Kanaly ST, Towne JE, Willis CR, Kuechle MK, Sims JE, and Peschon JJ. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. 2007. J. Exp. Med., in press.
Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J and J. Peschon. Interleukin 17 signals through a heteromeric receptor complex. 2006. J. Immunol. 177: 36-39.
Holland P, Willis C, Kanaly S, Glaccum M, Warren A, Charrier K, Murison J, Derry J, Virca G, Bird T, and Peschon J. RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation. 2002. Curr Biol. 12: 1424-1428.
Peschon JJ, Slack JL, Reddy P, K.L. Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, and Black RA. An essential role for ectodomain shedding in mammalian development. 1998. Science. 282: 1281-1284.
Peschon JJ, Torrance DS, Stocking KL, Glaccum MB, Otten C, Willis CR, Charrier K, Morrissey PJ, Ware CB, and Mohler KM. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. 1998. J Immunol. 160: 943-952.
Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, and Davison BL. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. 1994. J. Exp. Med. 180: 1955-1960.
|
|
|
home
