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Jennifer J. Smith
Area of Expertise
Genomics
Cell Biology
Current Position
Senior Research Scientist
Degree
Ph. D., Cell Biology, University of Alberta, Edmonton, Alberta, Canada, 2000
Research Interests
Dr. Smith is interested in understanding how discrete subcellular processes are coordinately regulated in response to stimuli and the relationship of this regulation to cell fitness. Towards this aim, she is characterizing the global response of yeast cells to fatty acid exposure through the generation, integration and analysis of various large-scale datasets.
Selected Publications
Ramsey S, Smith JJ, Orrell D, Marelli M, Petersen TW, de Atauri P, Bolouri H, Aitchison JD. Dual feedback loops in GAL regulon enhance galactose induction rate in yeast. 2006. Manuscript submitted to Nature Genetics.
Smith JJ, Sydorsky Y, Marelli M, Hwang D, Bolouri H, Rachubinski RA, Aitchison JD. Expression and functional profiling reveal distinct gene classes involved in fatty acid metabolism. 2006. Mol Syst Biol. Doi:10.1038/msb4100051
Hwang D, Smith JJ, Leslie DM, Weston AD, Rust AG, Ramsey S, de Atauri P, Siegel AF, Bolouri H, Aitchison JD, Hood L. A data integration methodology for Systems Biology: experimental verification. 2005. Proc Natl Acad Sci USA. 102:17302-7
Marelli M, Smith JJ, Jung S, Yi E, Nesvizhskii AI, Christmas RH, Saleem RA, Tam Y-Y, Fagarasanu A, Goodlett DR, Aebersold R, Rachubinski RA, Aitchison JD. Quantitative Mass Spectrometry Reveals a Role for the GTPase Rho1p in Actin Organization on the Peroxisome Membrane. 2004. J. Cell Biol. 167:1099-1112
Smith JJ, Marelli M, Christmas RH, Vizeacoumar FJ, Dilworth DJ, Ideker T, Galitski T, Dimitrov K, Rachubinski RA, Aitchison JD. Transcriptome profiling to identify genes involved in peroxisome assembly and function. 2002. J. Cell Biol. 158:259-71.
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