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Lee Rowen
Area of Expertise
Genomics
Current Position
Senior Research Scientist
Degree
Ph.D., Biochemistry, Stanford University, 1977
Ph.D., Philosophy, Vanderbilt University, 1986
Research Interests
Dr. Rowen's research interests fall into the broad category of genomic landscapes: gene structure and organization, how genes are laid out along chromosomes, multigene families such as the vertebrate T cell receptor loci; comparative genomics; and sequencing technologies. As part of the International Human Genome Sequencing Consortium, she coordinated the effort to sequence major portions of chromosomes 14 and 15. She is also interested in the activity of building a scientific culture, asking questions such as: What fosters communication and interaction among scientists with different disciplinary training and worldviews? And, What do people need to have to be productive at different stages of their careers?
Selected Publications
Zody MC, Garber M, Sharpe T, Young SK, Rowen L, et. Al. Analysis of the DNA sequence and duplication history of human chromosome 15. 2006. Nature 440: 671-675
Cameron RA, Rowen L, Nesbitt R, Bloom S, Rast JP, Berney K, Arenas-Mena C, Martinez P, Lucas S, Richardson PM, Davidson EH, Peterson KJ, Hood L. Unusual gene order and organization of the sea urchin hox cluster. 2006. J Exp Zoolog B Mol Dev Evol. 2006 306:45-58
Rowen L, Williams E, Glusman G, Linardopoulou E, Friedman C, Ahearn ME, Seto J, Boysen C, Qin S, Wang K, Kaur A, Bloom S, Hood L, Trask BJ.
Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen. 2005. Mol Biol Evol. 22:1712-20
Daza-Vamenta R, Glusman G, Rowen L, Guthrie B, Geraghty DE. Genetic divergence of the rhesus macaque major histocompatibility complex. 2004. Genome Res. 14:1501-15
Glusman G, Kaur A, Hood L, Rowen L. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. 2004. BMC Evol Biol.4:43
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