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Qiang Tian
Area of Expertise
Stem Cell Biology
Proteomics
Genomics
Current Position
Senior Research Scientist
Stem Cell Group Leader
Degree
Ph.D., Microbiology and Molecular Genetics, Michigan State University, 2000
M.D., Tianjin Medical University, 1994
Research Interests
Dr. Tian leads the Stem Cell Group, which is pioneering integrated genomic and proteomic approaches for the interrogation of mammalian stem cells, primarily hematopoietic, embryonic, and cancer stem cells. The focus of his research is to identify better stem cell markers and to elucidate mechanisms governing stem cell self-renewal vs. differentiation through global mRNA and protein profiling and through the illustration of protein-protein interaction networks of key signal transduction pathways essential for both stem cell development and tumorigenesis, such as the Wnt/catenin pathway. The ultimate goal is to generate tissue-specific progenitor cells from stem cells for personalized regenerative medicine and to identify specific cancer stem cell markers for development of improved therapeutic intervention. Dr. Tian has initiated a number of stem and progenitor cell proteomics projects with leading academic (Stowers, Johns Hopkins, FHCRC) and industrial (Merck, Geron) partners. He also manages a multi-institution NIH program project for Dr. Hood—in collaboration with Drs. Weissman, Clarke, and Fuller at Stanford—to search for genes that regulate stem cells. Dr. Tian is also a visiting professor in the State Key Laboratory of Molecular Oncology at Peking Union Medical College/Chinese Academy of Medical Sciences.
Selected Publications
Tian Q. Proteomic exploration of the Wnt and β -catenin. 2006. Current Opinion in Molecular Therapeutics, invited review, in press
Tian Q, He XC, Hood L, Li L. Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3ζ. 2005. Cell Cycle. 4(2):215-6. Epub 2005 Feb 3
Tian Q, Feetham MC, Tao AW, He XC, Li L, Aebersold R, Hood L. Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt. 2004. Proc Natl Acad Sci U S A. 101(43):15370-5
Tian Q, Stapaniants SB, Mao M, Lee W, Feetham MC, Doyle MJ, Yi EC, Dai H, Thorsson V, Eng J, Goodlett D, Berger JP, Gunter B, Linsley PS, Stoughton RB, Aebersold R, Collins SJ, Hanlon WA, Hood L. Integrated genomic and proteomic analyses of gene expression in mammalian cells. 2004. Mol Cell Proteomics 3(10):960-9
He XC, Zhang J, Tong W-G, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. 2004. Nature Genetics. 36(10):1117-21
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