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Liz Gold
Area of Expertise
Regulatory networks
Cell biology and immunology
Current Position
Senior Research Scientist
Assistant Clinical Professor University of Washington
Attending Physician Everett Clinic Cardiology
Degree
M.D., Yale University, 1993
Research Interests
Dr. Gold's research focuses on the role of the macrophage in atherosclerosis. Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the United States. From early fatty-streak lesions to advanced plaques, macrophages are integral to the development and progression of atherosclerosis. Macrophages play critical roles in both lipid homeostasis and inflammation. Dr. Gold is studying the intersection of these two pathways by examining the complex patterns of transcriptional regulation of genes involved in macrophage lipid homeostasis and in the regulation of inflammation. Elucidation of the transcriptional networks involved in these processes should lead to novel therapeutic targets.
Selected Publications
Gold ES, Simmons RM, Petersen TW, Campbell LA, Kuo CC, Aderem A.
Amphiphysin Iim is required for survival of Chlamydia pneumoniae in
macrophages. 2004. J Exp Med. 200:581-586
Matsumoto M, Einhaus D, Gold ES, Aderem A. Simvastatin augments
lipopolysaccharide-induced proinflammatory responses in macrophages by
differential regulation of the c-Fos and c-Jun transcription factors. 2004. J
Immunol. 172:7377-7384
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A.
Amphiphysin Iim, a novel amphiphysin II isoform, is required for macrophage phagocytosis. 2000. Immunity 12:285-92
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A.
Dynamin 2 is required for phagocytosis in macrophages. 1999. J Exp Med
190:1849-56
Morrissette NS, Gold ES, Guo J, Hamerman JA, Ozinsky A, Bedian V,
Aderem A. Isolation and characterization of monoclonal antibodies
directed against novel components of macrophage phagosomes. 1999. J Cell Sci 112:4705-13
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