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Ramsey Saleem
Area of Expertise
Cell Signaling
Cell Biology
Proteomics
Functional Genomics
Current Position
Senior Research Scientist
Degree
Ph.D., Medical Genetics, University of Alberta 2003
Research Interests
In my current research at the Institute for Systems Biology, I have been developing approaches to study the composition and
topology of cellular signaling networks. I use genome-wide functional genomics, in combination with mass spectrometry-based,
global proteomic approach to study the regulators and targets of the reversible phosphorylation system.
Using these techniques, in combination with data integration and network visualization, I have developed a preliminary
model of the network architecture for the signaling network governing responses to fatty acids. My current research program
is building on my novel findings. I am using these powerful, systems level approaches to study the information flow within
the signaling network, including crosstalk with other signaling pathways, and develops a temporally and spatially
resolved model with predictive value.
Selected Publications
Saleem R.A., Rogers R.S., Ratushny A., Dilworth D.J., Shannon P.T., Shteynberg D., Wan, Y., Moritz R.L., Nesvizhskii A.I., Rachubinski R.A., Aitchison J.D. (2010). Integrated Phosphoproteomic Analysis Reveals Conservation of Scale Free Properties in a Nutrient Responsive Signaling Network. In Press, Molecular and Cellular Proteomics.
Saleem R.A., Long-O'Donnell R., Dilworth D.J., Armstrong A.M., Jamakhandi A.P., Wan Y., Knijnenburg T.A., Niemistö A., Boyle J., Rachubinski R.A., Shmulevich I., Aitchison J.D. (2010). Genome-Wide Analysis of Effectors of Peroxisome Biogenesis. In Press, PLoS One.
Dilworth D.J., Saleem R.A., Rogers R.S., Aitchison J.D. (2010). QTIPS: A novel method of unsupervised determination of heavy amino acid incorporation in SILAC experiments. In Press, Journal of the American Society for Mass Spectrometry.
Saleem R.A., and Aitchison, J.D. (2010). Systems Cell Biology and the Mitotic Spindle. Journal of Cell Biology, 188: 7-9.
Wan, Y., Chiang, J.H., Lin, C.H., Arens, C., Saleem, R.A., Smith, J.J., Aitchison, J.D. (2009). Histone Chaperone Chz1p Regulates H2B Ubiquitination and subtelomeric anti-silencing. Nucleic Acids Research, doi: 10.1093/nar/gkp1099.
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